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David Smith, MD, MAS

Director, PREPARE Institute
Protocol Co-Chair, ACTIV-2 
Head, Division of Infectious Diseases and Global Public Health
Professor and Vice-Chair of Research, Department of Medicine
Co-Director, San Diego Center for AIDS Research (CFAR)
Florence Riford Seeley Chair in AIDS Research
UC San Diego

Davey Smith, MD, MAS, is an infectious disease specialist and translational research virologist. In his translational research, he uses basic science techniques to answer clinically relevant questions. Dr. Smith's primary research involves both figuring out how to stop the transmission of HIV and curing HIV, and he has published over 200 scientific publications in these areas. In 2010, Dr. Smith was named HIV Researcher of the Year by the HIV Medical Association, and he became the co-director and principal investigator of the San Diego Center for AIDS Research (CFAR) in 2016.

Since the outbreak of SARS-CoV-2 in 2019, Dr. Smith has been actively engaged in the international effort to find safe and effective treatments. In particular, he is the international protocol chair for the ACTIV-2 treatment study, which is a part of the US government’s Operation Warp Speed. This study is designed to find effective therapies for persons with early COVID-19.

Dr. Smith graduated from East Tennessee State University School of Medicine in 1996. He completed his internship, residency and chief residency in Internal Medicine at UC San Diego and stayed to complete his fellowship in Infectious Diseases. He joined the UC San Diego faculty in 2003, and was promoted to full professor in 2012. In 2017, he was promoted to Head of the Division of Infectious Diseases and Global Public Health at UC San Diego. In 2020, he was appointed the Florence Seeley Riford Chair in AIDS Research at UC San Diego. He has been elected as a fellow to the American Society of Clinical Investigation, American College of Physicians, and Infectious Diseases Society of America.

Bio from UC San Diego proflle

Click here for full list of publications

Recent publications:

AI-guided discovery of the invariant host response to viral pandemics. bioRxiv. 2021 Apr 13. Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Alexander LEC, Duran J, Crotty S, Dan JM, Das S, Ghosh P. PMID: 32995790. 
View in: 
PubMed 

High Prevalence of HIV-1 Drug Resistance and Dynamics of Transmission Among High-Risk Populations in Port-au-Prince, Haiti. J Acquir Immune Defic Syndr. 2020 12 01; 85(4):416-422. Jean Louis F, Domercant JW, Ignacio C, Gianella S, Galbaud G, Leonard M, Smith DM, Chaillon A. PMID: 33136738.
View in: PubMed 
"[It] is now my responsibility to fulfill that wish:" Clinical and rapid autopsy staff members' experiences and perceptions of HIV reservoir research at the end of life. PLoS One. 2020; 15(11):e0242420. Perry KE, Taylor J, Patel H, Javadi SS, Mathur K, Kaytes A, Concha-Garcia S, Little S, Smith D, Gianella S, Dubé K. PMID: 33206710.
View in: PubMed